The ability to determine the concentration of glucose without the need for pricking, i.e. non-invasively, is perceived as the most convenient way of glucose monitoring. Various attempts towards non-invasive glucose monitoring have been and are being reported in literature. The technologies behind these advances include, for example, near infrared spectroscopy, optical coherence tomography, Raman spectroscopy, Mie scattering, or fluorescence spectroscopy. The transmission of radiation through the human skin hereby appears to be the most preferred path towards revealing the concentration of glucose within the blood vessels. Furthermore, the aqueous humor in the eye or the interstitial fluid in skin may possibly provide information about the glucose concentration. However, despite the long history of the quest for non-invasive monitoring of glucose, no such systems are on the market so far. It is thus legitimate to have a closer look at the technical opportunities as well as challenges and hurdles in the field of non-invasive glucose monitoring.

The lecture, part of the Master of Science in Biomedical Engineering Course Technology and Diabetes Management, was given by Prof. Dr. Wolfgang Petrich from Roche Diagnostics, Mannheim, Germany. (Download the invitation).